2012-06-28

Polycystic kidney disease is a genetic disease?

Most patients as problems, in fact, kidney disease is a long-term development process from the beginning of pure ischemia and hypoxia caused cell injury, to later kidney fibrosis, large amounts of renal cell phenotypic transition, constitute unrecoverable scar tissue, in which the process of the development of kidney disease is like a speeding car, as long as people find the brake, we do have the opportunity to halt kidney disease. Polycystic kidney disease is a genetic disease? Halt kidney disease must reverse the damage to the kidneys, making it healthy again. Polycystic kidney disease is a genetic disease?, How to reverse the damaged kidney, we improve the state of renal ischemia and hypoxia, the expansion of the renal artery at all levels, to clear the pathogenic factor in the kidney and large amounts of extracellular matrix , two-phase conditioning the immune system of the kidney, to restore the immune function of the kidney, and repair damaged kidney cells, and ultimately restore the normal function of the kidneys. Understanding of polycystic kidney disease is a genetic disease?, See the following expert analysis:
Autosomal dominant polycystic kidney disease is a serious genetic disease, because of its onset usually after the reproductive age, causing the disease to the next generation, but for the history of the family, need appropriate medical legitimate. in order to reduce the incidence of future generations. With the development of treatment technologies, the prognosis of patients with polycystic kidney get to greatly improve, but the disease is currently still no specific eradication treatment. In recent years, the development of molecular genetics, the molecular basis of disease have a relatively clear understanding, but also provides a basis for the disease before the disease diagnosis and prenatal diagnosis.
Polycystic kidney disease patients may also have some complex situations, such as those without family history, most of the time is due to lack of understanding of the progenitor, but there are very few mutation results should cause a message. Parental renal ultrasound examination was normal children the disease is extremely rare, and their compatriots in polycystic kidney disease incidence is very low, to reconsider this type of patient, diagnose the problem, to ascertain whether acquired or drug-induced cystic disease .
As society advances, the mass of medical knowledge to improve, polycystic kidney disease genetic counseling more and more attention, many familial genetic history of people, especially couples of reproductive age are hoping to get a reasonable legitimate physicians to provide objective and comprehensive consulting to help patients make has left the right choice, and are very useful for reducing the occurrence of genetic disease, reduce the family burden.
Polycystic kidney disease prevention is a very important matter, and accurate diagnosis of examination, method of prenatal diagnosis and selective termination of pregnancy is a necessary condition to prevent polycystic kidney disease. The other hand, the early diagnosis of polycystic kidney disease family members bring important social and ethical implications, of course, its overall effect is more good than harm. Termination of pregnancy for patients is difficult to decide the issue, did not receive prenatal care based on DNA may be thought of polycystic kidney disease is a late onset disease, perhaps in another 10 years caused by polycystic kidney disease, kidney failure rule, making it difficult to make the choice of termination of pregnancy. The other hand, taking into account the control of blood pressure benefits of delaying progression of the disease, polycystic kidney disease family members are mostly willing to accept the ultrasound examination, once the lesions as early as possible for treatment. However, only a small number of high-risk family members were detected. Because the parents diagnosis curiosity, for the child and disease prevention are not beneficial. Therefore, the high-risk family members under the age of 18 do not advocate must make the disease before the inspection, enough for them over the line of blood pressure and renal function monitoring, diagnosis of the disease before the age of 18 is too much trouble. First of all, for 30 to 35-year-old member of ultrasound negative, the insured amount will usually increase the positive results, an increase of several times more. Once a muscle increase in liver, renal failure, can not be insured. PDK1 mutant family, the insurer also need proof of a DNA test negative in the conventional ultrasound and kidney function tests, in addition to the requirements of the insured, in order to provide insurance.

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