Autosomal dominant polycystic kidney disease (ADPKD) is generally a late-onset multisystem disorder characterized by bilateral renal cysts; cysts in other organs including the liver, seminal vesicles, pancreas, and arachnoid membrane; vascular abnormalities including intracranial aneurysms, dilatation of the aortic root, and dissection of the thoracic aorta; mitral valve prolapse; and abdominal wall hernias. Renal manifestations include hypertension, renal pain, and renal insufficiency. Approximately 50% of individuals with ADPKD have end-stage renal disease (ESRD) by age 60 years. The prevalence of liver cysts, the most common extrarenal manifestation of ADPKD, increases with age and may have been underestimated by ultrasound and CT studies. The prevalence of intracranial aneurysms is higher in those with a positive family history of aneurysms or subarachnoid hemorrhage (22%) than in those without such a family history (6%). Mitral valve prolapse, the most common valvular abnormality, occurs in up to 25% of affected individuals. Substantial variability in severity of renal disease and other extrarenal manifestations occurs even within the same family.
Diagnosis of ADPKD
Diagnosis of ADPKD is established primarily by imaging studies of the kidneys. In 85% of individuals with ADPKD, mutations in PKD1 are causative; in 15% mutations in PKD2 are causative. Molecular genetic testing for both genes is clinically available.
Who is affected?
ADPKD is uncommon - only 1 in every 1,000 people are born with the condition.
However, ADPKD is the most common genetic condition to affect the kidneys. It is estimated that around 50,000 people in the UK currently have ADPKD symptoms or will develop the condition at some point.
Micro-Chinese Medicine Osmotherapy treatment for Autosomal dominant polycystic kidney disease
Micro-Chinese Medicine Osmotherapy is the combination of Traditional Chinese Medicines and the advanced western technology. It is no surgery at all and does not cause any pains or traumas to the patients. It aims at the root cause---shrinking cysts, repairing kidney damages and enhancing the immunity so that it takes durable and lasting effects.
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