Proteinuria on the hazards of children with nephrotic syndrome:

Various types of protein, proteinuria, plasma can be lost, causing several metabolic disorders and dysfunction, and even complications occurred. Hypoalbuminemia itself or associated with low-expansion pressure of lipid metabolism can change, along with lecithin - cholesterol acyltransferase-converting enzyme from the urine, resulting in hypercholesterolemia, then the proportion of different types of lipoprotein and activity changes, prone to cause vascular endothelial damage and impaired renal function, the cardiovascular disease risks.
2, urinary protein excretion and protein synthesis changes, loss of balance in vivo coagulation factors and anticoagulant factors, increased clotting factors II, III, IV, and Ⅴ and the Ⅹ level, the body's clotting mechanism, platelet activity, thrombolytic process disorders. Therefore, the blood in children with nephrotic syndrome in a hypercoagulable state, are at high risk of thrombosis sick.
With urinary protein can also be a variety of other protein loss would give rise to the corresponding results, such as vitamin D-binding globulin is lost, resulting in abnormal vitamin D and calcium metabolism, vitamin D deficiency, hazards of proteinuria in children with nephrotic syndrome . Affect bone development of children. Thyroid binding globulin and albumin loss caused by thyroid dysfunction, thereby affecting the growth and development in children.
Hypoproteinemia caused edema of the nephrotic syndrome in children: nephrotic syndrome in children with blood albumin with the urine, resulting in hypoalbuminemia and blood vessel dilation pressure drop, fluid water into the tissue space, the occurrence of edema. Eyelid edema of the nephrotic syndrome in patients with edema in the early onset seen in early morning, and then spread to the legs, back, abdomen, or even the whole body. Edema is one of the nephrotic syndrome with characteristic clinical manifestations, and often the direct cause of parents with children seeking treatment.
Hypoproteinemia children with nephrotic syndrome: hypoalbuminemia and edema caused by hypovolemia, resulting in the renin - angiotensin - aldosterone axis irritation caused by sodium retention. So that some of the nephrotic syndrome in children to produce high blood pressure, oliguria, sinus tachycardia and other symptoms, especially prevalent in patients with minimal change nephrotic syndrome. Proteinuria in children with nephrotic syndrome harm. Therefore, children with nephrotic syndrome edema must be given full attention. Edema is the symptoms should be treated and more difficult to work. Treatment measures including salt restriction, diet, and taking diuretic drugs.Children with nephrotic syndrome with pleural effusion, ascites affect breathing and oliguria can be used furosemide, hydrochlorothiazide plug, or spironolactone.