2012-07-11

Do you have symptoms of Polycystic Kidney Disease

Polycystic kidney disease (polycystic kidney disease, PKD) is a common genetic kidney disease, mainly for bilateral kidneys appear many sizes cyst, cyst progressive increase, eventually destroying the kidney structure and function, leading to end-stage renal failure.
1) renal cyst: ADPKD patients with many of the symptoms of kidney cyst development are closely related. Renal cortex and medulla exist multiple fluid cysts, from a few millimeters in diameter to a few centimeters differ, the size of the cyst, and the number with progression and increase gradually. Male patients increased renal cyst degree of patients with higher than women.
(2) pain: back or rib abdominal pain is the most common symptom of ADPKD patients. Along with the age and cyst gradually obvious increase symptoms, women more common. Acute pain or pain usually indicates cyst burst suddenly aggravate bleeding, stones or blood clot cause urinary tract obstruction and amalgamative infection. Chronic pain is more than the increase of kidney or cyst to drag the renal capsule, kidney di, oppression adjacent organs to cause. Huge can cause liver cyst right rib pain.
(3) bleeding: more than 90% of the patients have the capsule hemorrhage or gross hematuria. For more spontaneous, can also occur in vigorous exercise or traumatic. The reason cause hematuria have cyst ruptured vessel, stones, infection or cancerous, etc. General hematuria all have self-limited, 2 ~ 7 days to disappear. If the bleeding for 1 week above or patients older than 50 years old, should be ruled out cancerous possibility.
(4) hypertension: is the most common ADPKD patients of one of the early performance. Normal renal function of the young ADPKD patients, 50% higher than 140/90 mmHg blood pressure, and in patients with end-stage renal disease in almost 100% had hypertension. High and low blood pressure and kidney cyst size, how many were positively than relationship, and increase with age upwards.
(5) renal damage: early renal damage often present as a kidney function decline enrichment. Most of the patients in the growth of the cyst from 40 to 60 years old years can maintain normal renal function; Once kidney began to fall, their glomerular filtration rate drop speed every year about 4.4 ~ 5.5 ml/min, from renal damage to end-stage renal disease development time of about 10 years.
(6) other: 20% ADPKD were associated kidney stones, uric acid and (or) calcium oxalate stone. Urinary tract infection is a common complication and cyst, retrograde infection as the main way. And the general population, compared with ADPKD renal cell carcinoma of the earlier age of onset, symptoms, and vulnerable to bilateral sarcoma center sample more metastases.

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