Introduction of Creatinine

Clinical detection of serum creatinine is one of the main methods for common understanding of renal function. Creatinine is how it all about? Endogenous creatinine is a product of the metabolism of human muscle. In muscle, creatine is mainly by the irreversible non-enzymatic dehydration reaction slowly formed creatinine, and then released into the bloodstream, with the urinary excretion. Serum creatinine and total body muscle are closely related and difficult to influence by diet. Creatinine small molecules, very little absorption by glomerular filtration in the renal tubules, creatinine, daily body produces almost all of the urine, usually from urine affect. Renal insufficiency, creatinine, harmful toxins accumulate in the body. Plasma creatinine, the upper limit of normal value is of about 100 micromoles / liter. Different hospitals are not the same testing standards, but no more than 120 micro mol / l. Within the kidney per unit time, the number of milliliters of plasma endogenous creatinine all cleared out, known as endogenous creatinine clearance rate (Ccr). Endogenous creatinine clearance test, and may reflect the number of glomerular filtration rate and a rough estimate effective renal units, so the quantitative test for the determination of renal damage. Because of its simple operation, less interference factors, higher sensitivity, better renal function tests widely used in clinical.
High serum creatinine values
Changes in the serum creatinine concentration is determined mainly by glomerular filtration (glomerular filtration rate). Filtration capacity decreased, the creatinine concentration increased. Serum creatinine value above normal most of the mean kidney damage, and serum creatinine can be a more accurate response to renal parenchymal damage is not sensitive indicators. Glomerular filtration rate decreased to the normal 1 / 3:00, serum creatinine was increased significantly. Means that, because the ability of human kidney metabolism, the general feeling of discomfort is not obvious when the kidney damage is light, so many people when the real nausea, vomiting, dizziness, in fact, the kidney has been injury is serious, this time serum creatinine also significantly increased by .
Creatinine high hazards
One, sodium metabolic disorders: creatinine high will appear hyponatremia or hypernatremia. Potassium metabolic disorders: creatinine higher than normal accompanied by hyperkalemia or hypokalemia. Third, water metabolism disorders: polyuria, nocturia, increased thirst, dry mucous membranes, weakness; or generalized edema, elevated blood pressure, pulmonary edema and heart failure. There will be aluminum, magnesium, copper, zinc, selenium and metabolic abnormalities. Renal osteodystrophy: bone pain and proximal muscle weakness; pain often systemic discreet bone to the lower body for weight, skeletal deformities can cause symptoms such as short stature. Metabolic acidosis: high creatinine of patients may have to breathe deep and long, lack of appetite, abdominal pain and nausea, vomiting, weakness, headache, irritability and even coma and other symptoms.
Seven: circulatory system diseases.
Eight: digestive system disease. Nine, blood system diseases, such as is renal anemia and so on.
10. Respiratory system diseases.